The Intersecting Storage Rings produced the world’s first proton-antiproton collisions on 4 April 1981, paving the way for proton-antiproton collisions in the Super Proton Synchrotron (SPS), and the Nobel prize for Simon van der Meer and Carlo Rubbia.

The ISR proved to be an excellent instrument for particle physics. By the time the machine closed down in 1984, it had produced many important results, including indications that protons contain smaller constituents, ultimately identified as quarks and gluons.